相关实验视频
Updated: Aug 17, 2026

08:41
Mouse Round Spermatid Injection
Published on: January 26, 2024
646
针对非男性不孕症的ICSI:从无效到性别偏见?
Edgardo Somigliana1, Giussy Barbara2, Laila G Micci3
1Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, ART Unit, Milan, Italy..
Reproductive biomedicine online
|February 15, 2025
概括
内细胞质精子注射 (ICSI) 应保留给男性不孕症病例. 它在其他不孕症类型中的过度使用没有提供活产优势,可能会增加风险,需要恢复传统体外受精 (IVF).
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 辅助生殖技术 辅助生殖技术
背景情况:
- 内细胞质精子注射 (ICSI) 是广泛使用的,但通常用于没有明显男性因子不孕症的病例.
- 有证据表明,ICSI的有效性仅限于男性不孕症,对其他原因有疑问的好处.
- 人们对ICSI对活产率,新生儿发育不良,资源利用率和性别比率的影响存在担忧.
研究的目的:
- 根据当前的证据,评估ICSI的适当使用.
- 为了比较ICSI与常规体外受精 (IVF) 的结果,用于各种不育症候群.
- 突出与不分青红白地使用ICSI相关的风险.
主要方法:
- 对现有的科学文献和有关ICSI疗效和安全的证据的审查.
- 在ICSI和常规试管婴儿之间对活产率,发育缺陷率和资源需求的比较分析.
- 评估ICSI对出生时性别比例的潜在影响.
主要成果:
- 与传统试管婴儿相比,ICSI并没有改善非男性因子不孕症的活产率.
- 使用ICSI可能与新生儿形的风险增加有关.
- ICSI绕过了自然精子选择,可能会影响生殖结果和性别比,有利于女性婴儿.
结论:
- 不分青红白地使用ICSI在科学上是不合理的,应该加以限制.
- 对于没有男性因素的不孕症病例,建议重新转向传统的试管婴儿.
- 应解决诸如受精失败的恐惧或依赖植入前遗传测试等障碍,以减少ICSI过度使用.
相关概念视频
Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...

