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在非肥胖的东亚成年人中,动脉样硬化指数和糖尿病风险之间的非线性关系

Jun Cao¹, Jitong Liu², Ke Yu³

¹Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital (Gannan Medical University Affiliated Municipal Hospital), Ganzhou, 341000, China.

Scientific reports

|February 15, 2025

概括

动脉样硬化指数 (AI) 与非肥胖成年人糖尿病风险增加有关. 降低AI可能会显著降低未来糖尿病发病率在这个人群.

科学领域:

心血管健康心血管健康
代谢障碍代谢障碍代谢障碍
流行病学流行病学

背景情况:

以前的研究表明,动脉样硬化指数 (AI) 与未来糖尿病风险之间存在积极联系.
关于非肥胖人群中这种关联的证据仍然有限.

研究的目的:

研究动脉样硬化指数 (AI) 与非肥胖的东亚成年人患糖尿病的风险之间的关系.
探索AI与糖尿病风险之间的潜在非线性关联.

主要方法:

一项回顾性队列研究,涉及来自中国和日本的95,402名非肥胖成年人.
考克斯比例危险模型和立方线被用来评估基线AI和发病糖尿病之间的关联,平均随访时间为3.01年.
为相关的共变量进行了调整,并进行了敏感性分析,以确保结果的稳定性.

主要成果:

在同变量调整后,在非肥胖成年人中观察到AI和糖尿病风险之间存在显著的积极关联 (HR1.09,95% CI1.03-1.15).
确定了一种非线性关系,其拐点在AI 1.47. 更高的AI值显示出与糖尿病风险的更强的关联.
敏感性分析证实了这些发现的可靠性.

结论:

这项研究表明,在非肥胖成年人中,动脉样硬化指数 (AI) 和未来糖尿病风险之间存在积极的非线性关联.
旨在减少AI的干预措施可能是预防糖尿病的有价值策略.

关键词:

动脉样硬化指数指数糖尿病糖尿病糖尿病东亚地区的东亚地区.非线性非线性没有肥胖的成年人.关系关系关系关系的关系

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