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工程多响应酸/PNIPAM/碳纳米管纳米复合物水凝作为按需药物输送平台

Bo-Yan Li¹, Tung-Yi Lin^1,2, Yi-Jhen Lai¹

¹Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan.

Small (Weinheim an der Bergstrasse, Germany)

|February 16, 2025

概括

这项研究引入了一种新的多响应纳米复合材料水凝,用于控制药物输送. 水凝利用第二次近红外 (NIR-II) 光进行远程激活,并在体外和体内表现出有效的药物释放.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

第二次近红外 (NIR-II) 响应性水凝提供远程激活和生物医学用途的深层组织透.
单反应性水凝在复杂的临床环境中存在局限性.
开发多反应性水凝对于先进的药物输送系统至关重要.

研究的目的:

开发一种新的多响应纳米复合材料水凝,用于增强可控药物释放.
集成多个刺激响应元素,用于多功能应用.
为了评估水凝在NIR-II辐射下药物输送中的性能.

主要方法:

合成了一种纳米复合水凝 (APN/PP-CNT) 使用酸二甲基 (ADA),聚乙烯胺 (PEI),聚N-异烯胺 (PNIPAM) 和功能化的多壁碳纳米管 (PP-CNT).
使用动态共价键 (胺和酸乙烯) 来形成水凝网络.
嵌入PNIPAM用于在NIR-II光照暴露时温度触发的药物释放.

主要成果:

该APN/PP-CNT水凝对多种刺激表现出反应性:pH,过氧化,温度和NIR-II光.
使用NIR-II光照射实现了有效的药物释放,证明了远程控制.
观察到成功的体外和体内药物释放性能,验证了它的潜力.

结论:

开发的APN/PP-CNT纳米复合液凝是可控药物输送的有希望的平台.
它的多响应性和NIR-II光激活使其更适合临床应用.
这种水凝为先进的治疗策略提供了多功能和有效的解决方案.

关键词:

在NIR-II响应的响应.碳纳米管的使用方法具有动态的共价键.纳米复合材料的水凝.

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