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MAFLD亚型和空气污染物与多系统发病率和全因死亡率的关联:一项前性队列研究

Jingyi Zhang¹, Shanshan Ran¹, Shengtao Wei¹

¹Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Ecotoxicology and environmental safety

|February 16, 2025

概括

空气污染加剧了与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 患者的风险,特别是增加了肝硬化,冠状动脉疾病和慢性病的风险. MAFLD-糖尿病患者面临的风险最高,需要有针对性的干预措施.

科学领域:

环境健康环境健康
肝病学肝病学是一种肝病学.
心脏病学心脏病学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

与代谢功能障碍相关的脂肪肝病 (MAFLD) 和空气污染是全球重大健康挑战.
对MAFLD和空气污染对多系统疾病和死亡率的综合影响尚不清楚.

研究的目的:

研究MAFLD亚型和空气污染对多系统发病率和全因死亡率的联合影响.
在英国生物银行参与者中探索空气污染物和MAFLD之间的附加和乘法相互作用.

主要方法:

分析了434,417名英国生物库参与者,分为非MAFLD,MAFLD-糖尿病,MAFLD-瘦身和MAFLD-超重/肥胖组.
使用可变时间的考克斯比例危险模型来评估暴露于PM2.5,PM10,NO2和NOx.
研究了空气污染物,MAFLD亚型和健康结果之间的关联和相互作用.

主要成果:

MAFLD-糖尿病显示出与不良结果的最强相关性.
空气污染在所有MAFLD亚型中协同增加肝硬化风险,特别是在MAFLD-lean组中的PM2.5和NO2中.
冠状动脉疾病 (CAD) 和慢性病 (CKD) 与特定空气污染物和MAFLD亚型,特别是MAFLD-糖尿病的积极相互作用被发现.

结论:

MAFLD亚型对发病率和死亡率有不同的影响,需要量身定制的预防和治疗.
空气污染与MAFLD有显著的相互作用,增加了肝硬化,CAD和CKD的风险.
由于与空气污染暴露相关的风险增加,MAFLD-糖尿病患者需要特别注意.

关键词:

这是一个ASCVD.环境空气污染环境空气污染在CKD中,它是最好的.肝硬化是肝硬化的一种.马夫尔德 (MAFLD) 是一个

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