在怀孕期间与多环芳结合的颗粒物个人接触,以及带炎症和氧化应激
Xuan Zhang1, Jia Wang2, Yan Wu3
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Ecotoxicology and environmental safety
|February 16, 2025
概括
产前暴露于与细颗粒物 (PM2.5) 结合的多环芳 (PAHs) 与新生儿的炎症和氧化应激标志物增加有关. 这项研究强调了潜在的风险,敦促进一步研究缓解策略.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 围产儿医学 围产儿医学
背景情况:
- 暴露于与细颗粒物 (PM2.5) 结合的多环芳 (PAH) 是对不良产前健康结果的新兴问题.
- 了解这些暴露对胎儿发育的影响对于公共卫生干预至关重要.
研究的目的:
- 调查产前暴露于与PAH结合的PM2.5和带血中炎症和氧化应激的标志物之间的关联.
- 评估特定PAH原体对这些生物标志物的单个和混合作用.
主要方法:
- 对450对母婴对进行前性研究,采用个人空气样本,以评估怀孕期间与PAHs结合的PM2.5暴露.
- 在带血液中测量炎症性 (TNF-α,IL-6,IL-8,TGF-β) 和氧化应激 (PAB) 生物标志物.
- 应用多变量线性回归,定量g计算和贝叶斯内核机器回归 (BKMR) 进行关联和混合分析.
主要成果:
- 在产前暴露于特定的PAH和TNF-α,IL-8和TGF-β水平的增加之间发现了显著的关联.
- 混合物分析表明了剂量反应关系,增加的PAH暴露与炎症和氧化应激标志物升高相关.
- 没有观察到IL-6和PAB的显著关联.
结论:
- 产前暴露于与PAHs结合的PM2.5与新生儿的炎症和氧化应激反应加剧有关.
- 这些发现强调了产前PAH暴露的潜在健康风险,需要进一步研究保护策略.
- 这项研究强调了在怀孕期间减少环境污染物暴露的重要性.
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