桌面和不同的小型近红外光谱仪应用研究:校准转移和2D-COS用于HPMC中的水分含量现场分析
Jianan Yue1, Hui Zhang2, Lele Gao1
1NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012 China; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Jinan 250012 China.
微型近红外 (NIR) 光谱仪显示出对现场分析的希望,但缺乏长板仪器的准确性. 这项研究使用了改进的主要成分分析 (IPCA) 来提高小型光谱仪的性能,以分析水分.
科学领域:
- 分析化学 分析化学
- 频谱学是一种光谱学.
背景情况:
- 微型近红外光谱仪 (NIR) 越来越多地被要求进行现场分析.
- 它们的预测准确性目前落后于传统的基板谱仪.
研究的目的:
- 评估小型NIR光谱仪的性能,用于在基甲基纤维素 (HPMC) 中进行定量水分分析.
- 用校准转移方法提高微型光谱仪的精度.
主要方法:
- 我们比较了一台台式光谱仪 (Antaris II) 和五台微型光谱仪.
- 采用了改进的主要成分分析 (IPCA) 转移方法来标准化频谱.
- 使用二维相关谱 (2D-COS) 分析光谱差异.
主要成果:
- 基板光谱仪 (Antaris II) 提供了卓越的结果.
- IPCA方法提高了微型NIR光谱仪的精度和可靠性.
- 2D-COS分析显示了微型和基板光谱仪之间的差异,为模型改进提供了信息.
结论:
- 微型光谱仪需要方法上的改进,以与基板性能相匹配.
- 在优化微型NIR光谱仪性能方面,IPCA传输方法是有效的.
- 这项研究推动了针对特定应用的精确和可靠的小型化NIR光谱仪的开发.
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