对比的转录基因和共同表达网络分析确定了参与山羊热应激反应的关键基因模块
Mahesh Shivanand Dige1, Ankita Gurao1, Arnav Mehrotra2
1Division of Animal Genetic Resources, ICAR-National Bureau of Animal Genetic Resources, Karnal 132001, Haryana, India.
International journal of biological macromolecules
|February 16, 2025
概括
这项研究揭示了参与Jamunapari山羊耐热压力耐受性的关键基因和途径. 识别这些分子机制可以提高牲畜在热带气候中的性.
科学领域:
- 动物遗传学和动物基因组学
- 畜牧生理学 畜牧生理学
- 环境压力生物学
背景情况:
- 热压对畜牧业产生负面影响,特别是在热带地区.
- 了解分子机制对于改善山羊的耐热性至关重要.
研究的目的:
- 为了研究Jamunapari山羊热应激耐受性的分子机制.
- 为了确定与热弹性相关的关键基因和途径.
主要方法:
- 转录组分析和差异性基因表达.
- 权重基因共同表达网络分析 (WGCNA) 用于枢纽基因识别.
- 根据生理学参数,将山羊分为热中性 (TNG) 和热应力 (EHSG) 组.
主要成果:
- 在热应激山羊中确定了133个上调和501个下调的基因.
- 上调的途径包括NF-kappa B和MAPK信号传递.
- 与IL-17信号传递相关的下调基因;确定了TUFM,TOMM40和VCL等枢纽基因.
结论:
- 对Jamunapari山羊的热应激耐受性的分子洞察.
- 确定了用于增强耐热能力的育种计划的潜在遗传标.
- 研究结果支持改善牲畜在热带环境中的适应性.
相关概念视频
Responses to Heat and Cold Stress
13.3K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.3K
Ribosome Profiling
3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
What is Gene Expression?
8.4K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
8.4K
Protein Networks
2.2K
2.2K
Cell Specific Gene Expression
4.5K
4.5K


