在类风湿性关节炎中失调的循环RNA:细胞作用和临床前景
Mengshi Tang1, Hongxing Li2, Siyuan Chang1
1Department of Rheumatology and Immunology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Clinical Medical Research Center for Systemic Autoimmune Disease in Hunan Province, Changsha, Hunan 410011, China.
Autoimmunity reviews
|February 16, 2025
概括
循环RNAs (circRNAs) 显示为风湿性关节炎 (RA) 诊断和治疗的生物标志物具有前途. 这些分子调节RA的生物过程,并为难以治疗的病例提供潜在的治疗点.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性关节炎 (RA) 仍然是一个重要的医疗保健挑战,尽管治疗方面取得了进展.
- 新型生物标志物和疗法对于改善鉴定和缓解率至关重要,特别是在血清阴性和难以治疗的RA (D2T RA) 中.
研究的目的:
- 探索循环RNAs (circRNAs) 在RA的生物过程中的作用.
- 研究circRNAs作为RA的诊断生物标志物和治疗点的潜力.
主要方法:
- 关于RA病变发生过程中circRNAs的当前文献的综述.
- 分析circRNA功能,包括miRNA海绵和转录调节.
- 检查各种细胞类型 (纤维细胞类同胞细胞,淋巴细胞,巨细胞,软质细胞,MSCs) 和组织 (血液,同胞细胞,软骨) 中的circRNA表达.
主要成果:
- 失调的circRNAs在RA病变发生过程中起着关键作用,主要是通过miRNA海绵和转录调节.
- 循环RNAs涉及RA内的各种细胞类型,包括FLS,淋巴细胞,巨细胞,软质细胞和MSC,并且在外体内发现.
- 血液,突和软骨组织中改变的circRNA水平表明它们对RA的诊断潜力.
结论:
- 失调的circRNAs代表了RA诊断生物标志物和治疗点的新型储备.
- 对细胞和组织特异性circRNA的进一步研究可能会导致改善患者分层,治疗反应预测和RA的药物选择.
相关概念视频
The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K
T Cell Types and Functions
897
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
897
Genome-wide Association Studies-GWAS
12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.3K
Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K


