与较低的死亡风险相关的特定宏观营养素集群:来自NHANES 1999-2018年的证据
Jiaying Yu1, Yang Chen1, Defang Li1
1Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, PR China; Key Laboratory of Precision Nutrition and Health of Ministry of Education, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Journal of advanced research
|February 16, 2025
概括
特定的宏观营养素集群与较低的全因死亡风险有关. 这种饮食模式分析为改善健康结果的营养干预策略提供了洞察力.
科学领域:
- 营养流行病学 营养流行病学
- 预防慢性疾病 预防慢性疾病
- 公共卫生研究 公共卫生研究
背景情况:
- 不均衡的宏观营养素摄入与慢性疾病风险增加有关.
- 以前的研究往往集中在单个宏观营养素上,限制了全面的理解.
- 宏观营养素组成的复杂相互作用需要进一步研究.
研究的目的:
- 综合分析饮食宏观营养素集群与全因死亡率之间的关系.
- 确定与降低死亡风险相关的特定宏观营养素摄入模式.
- 以基于宏观营养素聚类的营养干预策略为基础.
主要方法:
- 从1999-2018年国家健康和营养检查调查 (NHANES) 中分析了26,615名成年人 (20至75岁).
- 使用三维立方体方法将宏观营养素摄入量分为24个群.
- 采用Cox比例危险建模和限制立方线 (RCS) 分析来评估死亡率关联.
主要成果:
- 在调整了混因素后,四个特定的宏观营养素集群与所有原因死亡率显著降低有关.
- 与较低死亡率相关的关键集群包括集群Pm:Fm:Cm,集群Pm:Fmh:Cml,集群Pm:Fmh:Cm和集群Pl:Fm:Cmh.
- 在集群Pm:Fm:Cm中的碳水化合物摄入量和集群Pl:Fm:Cmh中的蛋白质摄入量以及整体死亡率之间观察到非线性关系.
结论:
- 具体的宏观营养素摄入组合,分类为集群,与较低的全因死亡率有关.
- 已识别的宏观营养素集群 (Pm:Fm:Cm,Pm:Fmh:Cml,Pm:Fmh:Cm,Pl:Fm:Cmh) 代表了潜在的保护性饮食模式.
- 宏观营养素聚类为开发有针对性的营养干预策略以减轻死亡风险提供了一种新的方法.
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