用放大器对白光内镜进行光学增强,用于检测胃肠道转化和新生病:一项随机对照试验
Meng Wan1, Guang-Chao Li1, Ming-Jun Ma1
1Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China; Shandong Provincial Clinical Research Center for Digestive Disease, Jinan, China; Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China; Robot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, China.
与放大内镜 (ME-OE) 结合的光学增强显著改善了胃肠代谢 (GIM) 的检测,与标准白光内镜 (WLE) 相比. 这种先进的技术在高风险患者中为GIM,胃内皮瘤 (GIN) 和早期胃癌 (EGC) 提供了更高的诊断产量.
科学领域:
- 胃肠病学 胃肠病学
- 内镜成像系统的成像
- 在瘤学瘤学.
背景情况:
- 通过白光内镜 (WLE) 检测胃肠转化症 (GIM),胃内皮瘤 (GIN) 和早期胃癌 (EGC) 往往是不够的.
- 需要改进内镜技术,以提高在胃中预癌和癌性病变的可视化和检测.
研究的目的:
- 评估光学增强与放大内镜 (ME-OE) 结合用于检测GIM,GIN和EGC的诊断价值.
- 为了比较ME-OE与常规WLE在高风险胃癌患者群体中的疗效.
主要方法:
- 一个随机对照试验,比较ME-OE和WLE在胃癌风险高的患者中.
- 患者被分配到ME-OE或WLE组,比例为1:1.
- 针对可疑病变进行了有针对性的活检,并分析了诊断产量,疗效和一致性.
主要成果:
- 与WLE (23.8%) (P = .018) 相比,ME-OE显示了GIM,GIN和EGC (36.6%) 的每患者诊断产量显著更高.
- 在ME-OE (66.7%) 与WLE (48.7%) (P = .017) 之间,每损伤诊断收益率也更高.
- 对于GIM检测,ME-OE显示了提高的灵敏度 (82.8%与54.3%,P = .003) 和积极的预测值 (88.9%与70.4%,P = .038),具有很好的观察者内部一致性 (κ = 0.81-0.83).
结论:
- 与放大内镜 (ME-OE) 结合的光学增强与标准白光内镜 (WLE) 相比,为检测胃肠代谢 (GIM) 提供了更高的性能.
- ME-OE是改善高风险个体癌前和早期胃病变的内镜诊断的宝贵工具.
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