基于CT的深度学习预测了食道状细胞癌患者的预后,这些患者接受了与化疗结合的免疫治疗
Xiaoyu Huang1, Yong Huang2, Ping Li3
1Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (X.H., P.L.).
Academic radiology
|February 16, 2025
概括
一个深度学习模型准确地预测了接受免疫疗法和化疗的食道状细胞癌 (ESCC) 患者的生存率. 整合成像和临床数据,该工具有助于个性化治疗策略,以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 人工智能的人工智能
背景情况:
- 免疫疗法与化疗相结合,为一些食道状细胞癌 (ESCC) 患者提供了改善的结果.
- 准确的治疗前风险分层对于优化ESCC治疗策略至关重要.
研究的目的:
- 开发和验证深度学习 (DL) 模型,用于预测ESCC患者接受免疫疗法和化疗的生存结果.
- 评估将周成像特征纳入DL模型的影响.
主要方法:
- 一个DL模型被训练在482个ESCC患者的追溯CT扫描在三个机构.
- 该模型分析了瘤和周围瘤区域,评估了不同的输入配置,包括感兴趣的扩展区域.
- 一个多式模式将DL衍生风险得分与临床和实验室特征集成,使用C指数和ROC曲线评估性能.
主要成果:
- 带有1像素周扩张的DL模型获得了最高的准确性 (C指数为0.75内部,0.60外部).
- 多式联运模型表现出可比性能 (C指数为0.74内部,0.61外部).
- SHAP分析确定了瘤反应,风险得分和年龄作为生存的关键预测因素.
结论:
- 开发的DL模型有效地根据生存风险对ESCC患者进行分层.
- 整合周成像和临床数据可以提高模型的预测能力.
- 这个模型显示了作为ESCC个性化治疗的预治疗工具的潜力.
相关概念视频
Tumor Immunotherapy
463
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
463
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Cancer Survival Analysis
321
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
321


