在阿尔茨海默氏病中,初级视觉皮层和小脑之间的功能连接发生变化
Chang Cai1, Takashi Kato1,2, Yutaka Arahata3
1Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Journal of Alzheimer's disease : JAD
|February 16, 2025
概括
在阿尔茨海默病 (AD) 连续体中,眼睛开放和眼睛关闭的情况会以不同的方式影响大脑功能连接 (FC). 阿尔茨海默病患者表现出逆向的V1-小脑连接性,这可能解释平衡问题并建议新的生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 开眼 (EO) 和闭眼 (EC) 状态在健康个体中不同组织大脑网络.
- 在EO/EC条件下使用静止状态fMRI进行功能连接 (FC) 分析,用于研究阿尔茨海默病 (AD).
- 眼睛疾病对整个AD连续性的CF的影响尚未得到充分证实.
研究的目的:
- 调查眼睛疾病 (EO与EC) 在整个阿尔茨海默氏病 (AD) 连续性中的功能连接性 (FC) 的影响.
- 探索CF模式如何在认知正常 (CN) 和轻度认知障碍 (MCI) 个体和没有粉样β (Aβ) 病理,以及在AD患者中,在EO和EC状态之间有所不同.
主要方法:
- 功能连接性 (FC) 通过使用AD连续 (CN-, CN+, MCI+, AD) 个体的初级视觉皮层 (V1) 种子来评估.
- 在双眼开放 (EO) 和双眼关闭 (EC) 条件下收集数据.
- 参与者包括59名β-PET阴性CN,14名β-PET阳性CN,24名MCI+和15名AD个体.
主要成果:
- 在所有组中,EO和EC条件都调节了V1和小脑 (后) 之间的FC.
- 在CN,CN+和MCI+组中,EO比EC更容易促进V1-大脑FC.
- 但AD组呈现相反的模式,EC显示V1-大脑的FC比EO更大. 在MCI+和AD组中,FC与EO下的树干余额相关.
结论:
- 在阿尔茨海默病 (AD) 中,视觉皮层 (V1) 和小脑之间的功能连接 (FC) 发生了改变.
- 这些V1-小脑连接性变化可能会导致AD患者的骨干平衡受损和跌倒.
- 在EO和EC条件下分析FC可以为AD检测和监测提供一种新的功能生物标志物.
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