使用光生物调节的口腔粘膜线索进行再生
Larissa Fassarela Marquiore1, Rafaela Ferrer Oliveira1, Luiza Almeida Queiroz Ferreira1
1Universidade Federal de Minas Gerais, Pampulha, Belo Horizonte, Brazil.
Lasers in medical science
|February 16, 2025
概括
近红外光生物调节疗法 (PBMT) 通过减少炎症和增强细胞修复,促进皮肤和口腔组织的再生. 这项研究表明PBMT.
科学领域:
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
- 组织再生 组织再生
背景情况:
- 光生物调节疗法 (PBMT) 越来越多地用于组织修复,但其对生体外介质相互作用的影响尚未完全理解.
- 了解细胞对PBMT的反应对于优化皮肤和粘膜损伤的治疗方案至关重要.
研究的目的:
- 调查近红外PBMT对应力角质细胞 (KC) 和它们与口腔纤维细胞 (FB) 的相互作用的影响.
- 评估PBMT对活性氧物种 (ROS),细胞活力,迁移和基因表达 in vitro 和 ex vivo 的影响.
主要方法:
- 单独培养KC或与FB共同培养,使用跨井系统,应用各种近红外光参数.
- 量化ROS水平,细胞活力,增殖和迁移.
- 在治疗细胞和ex vivo小鼠舌头碎片中分析了促决性和炎症性基因表达.
主要成果:
- 在应激细胞中,PBMT增加了ROS,但在体外增强了KC的活力,增殖和迁移.
- PBMT抑制了促炎性细胞因子和上调的安菲瑞古林,白内素1受体对抗剂和血管内皮生长因子.
- 活体舌头碎片显示,在PBMT后,自身膜厚度和状细胞数量增加.
结论:
- 近红外PBMT通过调节炎症和促进组织修复,表现出促再生效应.
- PBMT激活亲溶解分子和抑制细胞因子的能力支持皮肤环境中的早期组织重塑.
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