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Updated: May 27, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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TERT拼接的遗传调节通过改变细胞寿命和复制潜力来影响癌症风险

Oscar Florez-Vargas1, Michelle Ho1, Maxwell H Hogshead1

  • 1Laboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.

Nature communications
|February 16, 2025
PubMed
概括

端粒酶逆转录酶 (TERT) 基因中的遗传变异,特别是VNTR6-1和rs10069690,影响TERT拼接和表达. 这些TERT变异与癌症风险和端粒长度有关,影响细胞寿命.

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