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唾液微生物组概况在缩儿童的缩放后发生变化
Tasha Octaricha1, Cimi Ilmiawati2, Nila Kasuma3
1Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Andalas, Padang, Indonesia.
BMC research notes
|February 16, 2025
概括
缩水和根平整 (SRP) 改变了缩儿童的口腔微生物群,尽管没有观察到临床改善. 这项研究突出了SRP的重点.
科学领域:
- 儿科健康 儿科健康
- 微生物学 微生物学
- 口腔健康 口腔健康
背景情况:
- 由慢性营养不良引起的衰老会影响儿童的生长,并导致唾液腺功能障碍.
- 口腔失生症和牙周病风险增加是与衰老相关的唾液功能障碍的后果.
- 化和根平化 (SRP) 是一种标准的牙周治疗方法,用于减少有害的口腔细菌.
研究的目的:
- 评估SRP对儿童唾液口腔微生物组的影响.
- 为了比较SRP后缩儿童与正常儿童的微生物组变化.
主要方法:
- 一个测试前和测试后的研究设计被用在10名小学儿童 (正常和缩组) 上.
- 在SRP之前和之后收集了每个参与者的唾液样本.
- 下一代测序分析了口腔微生物组特征 (系,属,物种).
主要成果:
- 在正常儿童和发育不良儿童中,SRP诱导的微生物组概况发生了变化.
- 在SRP之后,占主导地位的菌群包括蛋白质细菌 (Proteobacteria),细菌杆菌 (Bacteroidota) 和杆菌 (Firmicutes).
- 临床参数 (牙指数) 在正常组有所改善,但在缩组没有.
结论:
- 在缩的儿童中,SRP改变了口腔微生物组合.
- 在被研究的衰退组中,SRP对牙周健康参数的临床益处并不明显.
- 需要进一步的研究,以了解SRP在缩人群中的长期影响和临床疗效.
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