可卡因用于预防鼻内输管过程中的出血:系统性审查
Mo Haslund Larsen1, Oscar Rosenkrantz1,2, Mette Krag1
1Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark.
Acta anaesthesiologica Scandinavica
|February 16, 2025
概括
局部可卡因在鼻内输管过程中不会显著减少表. 目前证据的确定性很低,需要对可卡因进行进一步的研究.
科学领域:
- 麻醉学 麻醉学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 鼻内输管带有表 (鼻血) 的风险.
- 用血管收缩剂缓解鼻腔粘膜的阻塞可以减轻这种风险.
- 可卡因具有降血和止痛功效,但也有潜在的副作用.
研究的目的:
- 系统地审查和分析局部鼻腔可卡因在减少鼻腔输管过程中表发生和严重性的疗效.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括随机临床试验,将鼻腔可卡因与比较剂或安慰剂进行比较.
- 评估了表发生和严重程度,疼痛,机械并发症和副作用;评估了偏差风险和证据确定性.
主要成果:
- 分析了6项试验 (457名参与者);其中一项具有偏见的低风险.
- 分析显示,可卡因和比较剂之间发生的表发生没有显著差异 (RR 0.90;95% CI 0.75-1.09;低确定性证据).
- 经症严重程度数据与分析不相容;疼痛,并发症和副作用数据稀少.
结论:
- 在鼻内输管中使用可卡因的证据数量和确定性较低.
- 关于可卡因与替代品相比的益处和危害,无法得出确定的结论.
- 需要进一步进行充足的随机试验,重点关注以患者为中心的结果,包括副作用.
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