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肺部由SARS-CoV-2感染引起的病变的形态病理学

Florin Ionuţ Buibaş¹, Roberta Andreea Cercel, Mircea Sebastian Şerbănescu

¹Doctoral School, University of Medicine and Pharmacy of Craiova, Romania; cercelroberta@gmail.com.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

|February 17, 2025

概括

尸检显示COVID-19患者的严重肺损伤,包括炎症,出血和纤维化. 这些发现有助于解释2019年冠状病毒病 (COVID-19) 死亡中出现的呼吸系统衰竭.

科学领域:

肺病理学肺病理学
法医医学法医学的医学.
传染性疾病传染性疾病.

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致全球大流行,导致冠状病毒疾病2019 (COVID-19).
COVID-19主要影响肺部,导致呼吸衰竭,肺栓塞,二次性肺炎和纤维化.
由于SARS-CoV-2引起的器官损伤的确切机制仍然不太清楚.

研究的目的:

为了调查死去的COVID-19患者的肺病变.
为了将肺病理与急性呼吸困扰综合征 (ARDS) 的复杂症状相关联.
为了阐明SARS-CoV-2引起的肺损伤的病原性.

主要方法:

在法律上可疑的情况下死亡的36名COVID-19患者的解剖检查.
肺组织的组织病理学分析,以确定炎症和纤维变化.
对血管病变,血栓形成和组织重塑的评估.

主要成果:

所有患者都表现出肺炎炎症反应与排泄和增殖现象.
重要发现包括膜内和间歇性炎症透物 (淋巴细胞,巨细胞,中性粒细胞).
观察到血管堵塞/破裂,出血,血栓,纤维细胞增殖,肌纤维细胞转化和颗粒组织形成,导致肺膜重塑.

结论:

该研究详细介绍了COVID-19死亡人群中广泛的肺病变,与ARDS一致.
研究结果强调炎症,血管损伤,血栓形成和纤维化是关键的病理特征.
观察到的肺病理学提供了关于COVID-19严重呼吸衰竭背后的机制的见解.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.冠状病毒冠状病毒的新冠病毒.这是一种炎症炎症炎症炎症.肺部疾病肺部疾病肺炎是一种肺炎.

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