孕产妇的童年创伤和婴儿从婴儿期到6岁的子女的下丘脑-垂体-上腺轴功能
Lisa Loheide-Niesmann1, Roseriet Beijers1,2, Carolina de Weerth2
1Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands.
Developmental psychobiology
|February 17, 2025
概括
在社区样本中,母亲的童年创伤没有显著影响儿童的压力激素水平 (皮质醇). 探索性发现表明,潜在的调节者,如母亲的产前心理病理学,可能会影响这种代际效应.
科学领域:
- 心理学 心理学 心理学
- 内分泌学 在内分泌学.
- 发展科学 发展科学
背景情况:
- 童年创伤可能对后代的健康和行为产生代际影响.
- 下垂体-垂体-上腺 (HPA) 轴是这些影响的潜在机制.
- 了解这些机制对于干预策略至关重要.
研究的目的:
- 检查母亲的童年创伤经历与孩子的HPA轴功能之间的关联.
- 为了研究12个月和6岁儿童的皮质醇反应性和总昼夜皮质醇输出.
- 探索创伤效应在代际传播中的潜在缓解因素.
主要方法:
- 长度研究170个母婴双.
- 评估母亲的童年创伤 (虐待,暴力).
- 在12个月和6岁时使用多级回归分析测量了儿童皮质醇反应性和昼夜输出.
主要成果:
- 在母亲的童年创伤和儿童皮质醇反应性或在任何时间点的总日间皮质醇输出之间没有发现显著的关联.
- 探索性分析表明,母亲的产前心理病理学和产前皮质醇倾斜率的适度.
- 母亲的童年创伤与高产前心理病理/皮质醇倾斜度的母亲的儿童皮质醇输出有积极的关联,而低水平的母亲的皮质醇输出有负面关联.
结论:
- 在这个社区样本中,母亲的童年创伤并没有直接影响幼儿的HPA轴功能.
- 孕产妇的精神病理和产前皮质醇模式可能会缓解童年创伤对儿童HPA轴的代际影响.
- 需要对不同人群和年龄较大的儿童进行进一步的研究来证实这些发现.
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