Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

139
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
139
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

DigiLoCS: A leap forward in predictive organ-on-chip simulations.

PloS one·2025
Same author

Distinct pathoclinical clusters among patients with uncontrolled type 2 diabetes: results from a prospective study in rural India.

BMJ open diabetes research & care·2022
Same author

Clustering Based Parameter Estimation of Thyroid Hormone Pathway.

IEEE/ACM transactions on computational biology and bioinformatics·2020
Same journal

GMSA: A Graph Matching and Point Cloud Registration-Based Method for Spatial Transcriptomics Data Alignment.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Investigations on Multiple Protein Scaffold Filling.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Cell Type Prediction for Single-Cell RNA Sequencing Utilizing Unsupervised Domain Adaptation and Semi-Supervised Learning.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

PPIGAN: Prediction of Protein-Protein Interactions Using Generative Adversarial Networks.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Deep Structure-Enhanced Cell Clustering Model for Single-Cell RNA Sequencing Data.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Asymmetric Drug-Drug Interaction Prediction Based on Generative Adversarial Networks and Knowledge Graph.

Journal of computational biology : a journal of computational molecular cell biology·2026
查看所有相关文章

相关实验视频

Updated: May 27, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

518

使用稀缺数据对初级甲状腺功能低下症进行特定对象的剂量估计.

Devleena Ghosh1, Chittaranjan Mandal1

  • 1Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India.

Journal of computational biology : a journal of computational molecular cell biology
|February 17, 2025
PubMed
概括
此摘要是机器生成的。

这项研究通过模拟患者特定的参数和使用先进的计算分析来估计针对低甲状腺症的个性化甲状腺药物剂量,以确定最佳药物范围,即使数据有限.

关键词:
药物管理建模药物管理建模参数估计的参数估计.满足性模块理论的满足性稀少的数据稀少的数据.甲状腺热调节路径

更多相关视频

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.0K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

相关实验视频

Last Updated: May 27, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

518
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.0K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

科学领域:

  • 计算生物学 计算生物学
  • 内分泌学 在内分泌学.
  • 数学建模的数学建模

背景情况:

  • 个性化医疗需要准确的剂量估计,如初级甲状腺功能低下症等条件.
  • 数据稀缺和参数不确定性挑战了传统的剂量优化方法.
  • 当模型参数具有固有的不确定性时,现有的优化技术可能会失败.

研究的目的:

  • 开发一种针对主体特定的剂量估计方法,用于原发性甲状腺功能低下症.
  • 在个性化建模中解决数据稀疏性和参数不确定性.
  • 用数学建模和先进分析来确定最佳药物剂量范围.

主要方法:

  • 使用治疗前和治疗后的观测,以不确定性估计了特定对象的模型参数.
  • 在普通微分方程模型中,使用富里埃数列近似来建模周期性药物管理.
  • 基于满意度模块理论 (SMT) 的分析被应用来确定最佳剂量范围.
  • 一个回归模型被用于初始剂量估计.

主要成果:

  • 开发并验证了计算程序,用于对特定患者的剂量估计.
  • 该研究成功估计了最佳药物剂量范围,尽管数据有限和参数不确定性.
  • 开发的方法为个性化甲状腺功能低下症治疗提供了强大的方法.

结论:

  • 基于SMT的分析有效地确定了原发性甲状腺功能低下症的最佳药物剂量范围.
  • 该方法适应参数不确定性,提高个性化剂量建议的可靠性.
  • 这项工作为内分泌学中的精密医学提供了一个新的计算框架.