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慢性病的认知障碍在不同阶段:结构和 perfusion 驱动的功能连接性变化的作用
Xiaoyan Bai1, Lijun Song1, Xu Liu2
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Brain and behavior
|February 17, 2025
概括
慢性病 (CKD) 与认知障碍 (CI) 有关. 晚期CKD阶段显示大脑结构和血液流动发生变化,特别是在状环,影响功能连接和认知得分.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 慢性病 (CKD) 是认知障碍 (CI) 的已知危险因素.
- 在CKD中CI的精确神经生物学基础仍然不完全理解.
- 调查大脑的结构和功能变化对于了解CKD相关CI至关重要.
研究的目的:
- 为了检查灰质体积 (GMV) 和脑血流 (CBF) 在CKD各个阶段的变化.
- 在CKD患者中识别具有功能连接 (FC) 改变的大脑区域.
- 为了将神经成像发现与认知测试表现相关联.
主要方法:
- 招募了208名参与者:66人为对照组,70人患有CKD 1-3a阶段,72人患有CKD 3b-5阶段.
- 使用高分辨率T1加权成像,动脉旋转标记 (ASL) 和功能性MRI (fMRI).
- 在不同组中比较成像参数,并分析与蒙特利尔认知评估 (MoCA) 成绩的相关性.
主要成果:
- 与CKD阶段1-3a相比,CKD阶段3b-5显示双边状 (FFG) 的GMV降低和CBF增加.
- 在晚期的CKD中,在FFG和认知相关区域 (例如下额头,海马) 之间观察到CF降低.
- 在CKD 1-3a阶段,较低的MoCA分数与改变的FFG FC相关,其中包括海马体和骨.
结论:
- 大脑中的结构和 perfusion 异常与 CKD 患者的 FC 降低有关.
- 这些神经成像发现表明,CKD认知障碍的潜在神经病理机制.
- 这项研究提供了证据,将大脑变化与CKD不同阶段的认知缺陷联系起来.
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