冲动性方面和物质使用参与:基因组结构方程建模的见解
Laura Vilar-Ribó1, Alexander S Hatoum2, Andrew D Grotzinger3,4
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Psychological medicine
|February 17, 2025
概括
特定的冲动性特征在遗传上影响物质使用和物质使用障碍 (SUD) 的不同阶段. 了解这些遗传联系可以为SUDs的预防和治疗策略提供信息.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学遗传学 精神病学遗传学
- 成研究 研究成研究
背景情况:
- 冲动性是一种与物质使用障碍 (SUDs) 相关的多维特征.
- 特定的冲动性方面与不同阶段的物质参与之间的精确遗传关系尚未得到充分理解.
研究的目的:
- 研究9种冲动性特征和7种物质使用 (SU) 和SUD特征之间的共同遗传结构.
- 确定哪些特定的冲动性方面与物质使用和SUDs的不同阶段遗传相关.
主要方法:
- 使用了基因组结构方程建模和全基因组关联研究 (GWAS),样本大小大 (N=79,729-903,147).
- 检查了冲动性特征和SU/SUD因素之间的潜在遗传相关性和独立遗传关联.
主要成果:
- 药物使用 (SU) 和SUD因素显示出强烈的遗传相关性 (r=0.77).
- 不同的冲动性方面表现出不同的遗传关联:缺乏预谋,负面的紧迫性和积极的紧迫性与SU和SUD有关.
- 感觉寻找与SU有更强的遗传相关性,而延迟折扣与SUDs有更强的联系. 在控制遗传重叠后,每个冲动性方面与SU或SUD因素出现了特定的独立遗传关联.
结论:
- 冲动性的特定方面为物质使用参与的不同阶段赋予了不同的遗传风险.
- 这些发现对制定药物使用障碍的有针对性的预防和治疗策略具有重大意义.
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