通过瘤微环境激活的细胞吸收和ROS敏感药物释放,通过使用双重敏感的纳米凝进行增强组合疗法
Jianming Yuan1, Qinfeng Chen1, Mingxiang Zuo1
1Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, PR China. chengdu@mail.sysu.edu.cn.
Biomaterials science
|February 17, 2025
概括
这项研究介绍了一种新型的双敏感纳米凝,用于有效的化学疗法和光动力学剂的联合递送. 纳米凝增强了药物输送和协同抗瘤效应,改善了组合治疗.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 化疗剂和光动力学剂的同时递送对临床应用具有挑战性.
- 开发高效的纳米平台以实现高效的共同交付效率至关重要.
- 现有的纳米平台往往面临着简单性和效率方面的局限性.
研究的目的:
- 开发一种简单高效的双敏感纳米凝,用于同时提供多克索鲁比 (DOX) 和绿色氨酸 (ICG).
- 通过向刺激响应机制,增强细胞吸收和药物释放.
- 为了评估联合递送的药物的协同作用的抗瘤作用.
主要方法:
- 逆迷你乳液聚合,以产生活性氧物种 (ROS) 和pH双重敏感的纳米凝.
- 同时封装多克索鲁比 (DOX) 和印洋氨酸绿色 (ICG) 结合的牛血清白蛋白 (BSA).
- 用含有基化 (CDM) 连接剂的基细胞透 (CPP) 进行修改,以增强细胞吸收.
主要成果:
- 纳米凝证明了对DOX和ICG的高联合交付效率.
- 瘤微环境触发的细胞吸收显著增强.
- 近红外 (NIR) 辐射触发了ROS生成和受控的药物释放,从而产生了协同作用的抗瘤效应.
- 化延长了血液循环时间,而去屏蔽暴露的CPPs改善了细胞内部化.
结论:
- 开发的双灵敏纳米凝提供了一个简单而高效的方法,用于联合治疗中的联合交付.
- 纳米凝系统有效地提高了协同作用的抗瘤疗效.
- 这个平台有望改善组合癌症治疗的临床应用.
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