越来越多的CAR-T疗法使用与干细胞移植的减少相结合,在6年期间使用稳定的资源:资源利用含义
Aswath P Chandrasekar1, Margret A DiGuardo1, Jeffrey L Winters1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Transfusion
|February 17, 2025
概括
采用CAR-T疗法正在上升,而造血干细胞移植 (HSCTs) 正在下降. 尽管有这些转变,但这些治疗的总体资源利用在六年内保持稳定.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 自2017年FDA批准以来,化学抗原受体T细胞 (CAR-T) 疗法经历了显著的临床增长.
- 在临床实践中观察到一个显著的转变,随着CAR-T疗法的使用越来越多,血液造血干细胞移植 (HSCTs) 的同时减少.
- 考虑到制造和储存的共同资源,了解这些不断变化的趋势至关重要.
研究的目的:
- 分析六年 (2018-2023) 的CAR-T疗法和HSCT利用趋势.
- 评估这些转变趋势对细胞疗法整体资源利用的影响.
主要方法:
- 以后回顾阿菲雷斯和实验室数据库的回顾.
- 包括接受CAR-T或自身HSCT采集和/或输液的患者.
- 从2018年1月1日到2023年12月12日,根据年份和疾病组分层次的数据分析.
主要成果:
- 卡特-T收藏量从52 (2018) 增加到150 (2023),而HSCT收藏量则从425 (2018) 减少到341 (2023).
- 汽车-T输液从24 (2018) 增加到111 (2023),相比之下,自动HSCT输液从400下降到289.
- 总体患者采集数量和采集程序保持稳定;在研究期间,总输液也没有显著变化.
结论:
- 这项研究证实,CAR-T治疗的采用率显著增加.
- 观察到HSCT程序的相应减少.
- 尽管有这些转变,但CAR-T和HSCT的整体资源利用仍然保持一致.
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