灰色质缩中的种族种族差异是由多发性硬化症中的结构性脱节介导的
Ahmed Bayoumi1, Joseph A Thomas1, Breanna R Alonzo1
1Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA.
Annals of clinical and translational neurology
|February 17, 2025
概括
来自黑人和西班牙裔/拉丁裔背景的多发性硬化症患者表现出较大的灰质缩. 白质病变和结构性脱节部分解释了多发性硬化症中的这些种族种族差异.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 临床神经学 临床神经学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 人们越来越认识到MS流行和进展的种族差异.
- 灰质 (GM) 缩是MS中神经退行的一个关键指标.
研究的目的:
- 调查MS患者中转基因缩的种族差异.
- 确定白质病变和结构性脱节对这些差异的贡献.
- 探索这些因素在不同种族群体中的调解作用.
主要方法:
- 对297名MS患者的回顾性分析:98名西班牙裔/拉丁裔 (H-MS),82名非西班牙裔黑人 (B-MS) 和117名非西班牙裔白人 (W-MS).
- 基于voxel的形态测量和基于源的形态测量用于评估转基因缩.
- 网络修改工具评估了结构性断开;调解分析探索了变量之间的关系.
主要成果:
- 黑人和西班牙裔/拉丁裔多发性硬化症患者比白人多发性硬化症患者表现出更大的转基因缩,特别是在部,副海马,前部和部区域.
- 在海马体,环带体,先体和深层GM中,结构性断网性差异突出.
- 损伤负载显著介导全球转基因缩 (52.4%),结构性断开介导了一些转基因组分差异.
结论:
- 在MS患者中,在转基因缩模式中存在显著的种族差异.
- 白质病变和结构性脱节部分介于这些差异.
- 研究结果强调,需要考虑民族种族因素来个性化MS治疗和临床试验多样性.
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