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在局部直肠癌中FDG PET-CT的预测作用:系统性审查和元分析

Leslie Zhi Wei Lew¹, Benjamin M Mac Curtain², Teck Siew^1,3,4,5

¹Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia, Australia.

Journal of medical imaging and radiation oncology

|February 17, 2025

概括

18-氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG PET-CT) 显示了直肠癌 (RC) 患者的预后潜力. 特定的指标,如SUVmax,TLG和MTV的百分比变化,可以预测结果,尽管SUVmax单独与生存无关.

科学领域:

在瘤学瘤学.
放射学放射学是指放射学
医疗成像医学成像

背景情况:

结直肠癌 (RC) 由于其高发病率和复发率而构成重大临床挑战.
目前的指导方针不建议常规的18-氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG PET-CT) 用于治疗后监测RC.
需要评估FDG PET-CT在RC管理中的预后效用.

研究的目的:

系统地审查和分析关于使用FDG PET-CT用于直肠癌患者预后的现有文献.
确定特定的FDG PET-CT指标,这些指标可以作为患者结果的有价值预测指标.

主要方法:

进行了全面的系统审查和对2024年5月19日之前发表的研究的元分析.
在包括PubMed,Embase,MEDLINE和Cochrane (Central) 在内的主要数据库中进行了搜索.
研究偏差使用修改后的纽卡斯尔-太华尺度进行评估,并为最大标准化摄入值 (SUV) 计算了无病生存期 (DFS) 和总生存期 (OS) 的聚合危险比率 (HR).

主要成果:

这项系统性审查包括了11项涉及771名患者的研究.
诸如SUVmax的百分比变化,总损伤糖解 (TLG),代谢瘤体积 (MTV) 和淋巴结中的最高峰SUV等指标显示出局部非转移性RC的潜在预测结果.
三个同质参数的聚合元分析表明,SUVmax (治疗前或后) 和生存结果 (DFS或OS) 之间没有显著的相关性.

结论:

虽然治疗前SUVmax与生存无关,但治疗后的FDG PET-CT指标需要进一步调查,以评估RC的预后.
特定的FDG PET-CT参数,如SUVmax,TLG和MTV的百分比变化,可能为局部RC提供预后价值.
需要额外的研究和数据来确定FDG PET-CT在预测直肠癌患者的预后结果中的作用.

关键词:

德国联邦财政总局PET 聚乙烯/聚乙烯/聚乙烯核医学是核医学的一种.结果就是结果.这是直肠癌.

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