在高血压患者中,Chlorthalidone和Hydrochlorothiazide之间的心血管结果的比较
Subin Lim1, Ju Hyeon Kim1, Seungmi Oh2
1Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Journal of clinical hypertension (Greenwich, Conn.)
|February 17, 2025
概括
甲 (CLTD) 和甲 (HCTZ) 是有效的高血压治疗方法. 这项研究发现,这两种药物都为患者提供了类似的心血管结果和安全概况.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 化物利尿剂,包括甲 (CLTD) 和化 (HCTZ),是高血压的第一线治疗方法.
- 在CLTD和HCTZ之间对长期心血管结果的比较数据有限.
- 了解有效性和安全性的比较对于临床决策至关重要.
研究的目的:
- 为了比较使用CLTD治疗的高血压患者与HCTZ治疗的心血管结果.
- 在现实临床环境中评估CLTD和HCTZ的安全性.
- 为在高血压管理中选择 thiazide 利尿剂提供基于证据的指导.
主要方法:
- 一个多中心的,回顾性队列研究,使用来自韩国大学医学中心的电子健康记录.
- 倾向性得分匹配 (1:1) 用于平衡CLTD和HCTZ组之间的基线特征.
- 分析包括主要不良心血管事件 (MACE),心血管死亡率,心肌梗塞和低血发病率.
主要成果:
- 在倾向得分匹配后,每组包括1606名患者 (CLTD与HCTZ).
- 三年内MACE的发生率相似:CLTD为1.2%,HCTZ为1.4% (HR为0.91,p=0.77).
- 二次结局,包括心血管死亡率和心肌梗塞,以及低血发病率在各组之间也相似.
结论:
- 甲和甲在降低高血压患者心血管事件方面表现出相似的疗效.
- 这两种 thiazide 利尿剂都表现出类似的安全性,包括低血的风险.
- 这些发现支持基于临床背景的CLTD或HCTZ用于高血压管理.
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