长期的乙型肝炎表面抗原动力学在核胺类同类药物中断后在非肝炎慢性乙型肝炎患者中
Lina Wu1,2, Jiadi Lai1,2, Qiumin Luo1,2
1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Liver research
|February 17, 2025
概括
在治疗结束时,乙型肝炎表面抗原 (HBsAg) 水平低于1000 IU/mL,预测在慢性乙型肝炎患者中核胺模拟物中止后,血清清除率更高. 建议进行密切监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性乙型肝炎 (CHB) 的治疗包括核酸类比 (NA) 疗法.
- 停止NA治疗需要了解B型肝炎表面抗原 (HBsAg) 的动力学.
- 有限的数据存在于长期的HBsAg动力学后NA停止在noncirrhoticCHB.
研究的目的:
- 为了研究长期的HBsAg动力学后,在患者中停产NA在非循环性CHB.
- 确定与HBsAg血清清除和水平下降相关的因素.
- 评估NA停止的安全性和结果.
主要方法:
- 预计将招募106名非心脏病性CHB的门诊患者,符合NA的停药标准.
- 在停药5年后收集和分析人口,临床和实验室数据.
- 评估HBsAg水平,血清清除和复发率.
主要成果:
- 在完成5年随访的96名患者中,12名 (17.9%) 实现了HBsAg血清清除.
- 治疗结束时 (EOT) HBsAg ≤1000 IU/mL的患者表现出较高的血清清除率 (33.3%) 与>1000 IU/mL (5.4%) 相比.
- EOT HBsAg水平是血清清除的独立预测指标,最佳切断值为359 IU/mL.
结论:
- 在非循环性CHB中中止NA是可行的,在一组患者中观察到HBsAg血清清除.
- 较低的EOTHBsAg水平 (≤1000 IU/mL) 与改善的HBsAg血清结局有关.
- 密切监测和准备进行NA再处理对于安全停用NA至关重要.
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