在早期青少年中短期暴露于相对湿度和肺部健康
Nicholas J Nassikas1, Wenli Ni1, Sheryl L Rifas-Shiman2
1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
暴露于极端湿度水平会影响青少年的肺部健康. 高湿度会增加呼吸道炎症 (FeNO),而低湿度会降低肺功能 (FEV1,FVC).
科学领域:
- 环境健康 环境健康
- 儿科呼吸系统医学 儿科呼吸系统医学
- 肺功能测试试验 肺功能测试
背景情况:
- 极端的湿度可以引发喘症状.
- 对湿度对青少年肺部健康测量的影响的理解有限.
- 在青少年中研究相对湿度 (RH) 和肺功能/FeNO之间的关联.
研究的目的:
- 评估短期暴露于高和低相对湿度 (RH) 和肺功能之间的关联.
- 在青少年中评估RH极端和部分呼出的氧化 (FeNO) 之间的关系.
主要方法:
- 利用了来自1019名青少年 (平均年龄13.2岁) 的预产前期队列的数据.
- 根据参与者的地址分配每日RH水平,并根据队列特定百分点定义低/高RH.
- 采用了通用的添加模型和分布式滞后非线性模型来分析RH对FEV1,FVC和FeNO在1-7天内的影响.
主要成果:
- 高RH (≥第90百分位) 与FeNO的38.0%增加有关.
- 低RH (≤10百分位) 与FEV1 (-186.2毫升) 和FVC (-130.2毫升) 的显著降低有关.
- 中位数RH为65.6%,第10个百分点和第90个百分点分别为47.2%和86.6%.
结论:
- 短期暴露于极端的RH水平会影响青少年的肺部健康.
- 高RH与呼吸道炎症 (FeNO) 的增加有关.
- 低RH与肺功能下降有关 (FEV1,FVC).
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