非特异性血液炎症生物标志物可以预测急性过渡性精神病障碍的恢复吗? 一个前性的观察研究
Jaya Prakash1, Sujita Kumar Kar1, Wahid Ali2
1Dept. of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Indian journal of psychological medicine
|February 17, 2025
概括
炎症标志物在第一期急性和过渡性精神病障碍 (ATPD) 患者中升高. 抗精神病治疗减少了这些炎症标志物,这表明炎症在ATPD中起作用.
科学领域:
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 炎症与精神疾病的发病有关.
- 急性和过渡性精神病障碍 (ATPD) 是一种由精神病症状突然发作所表现的疾病.
研究的目的:
- 测量在基线未服用药物,首发ATPD患者的炎症标志物.
- 为了评估三个月抗精神病治疗后这些标记物的变化.
- 探索炎症标志物变化与临床改善之间的关系.
主要方法:
- 前性研究设计.前性研究设计.
- 招募了78名先前没有服用过药物的患者,患有第一个ATPD.
- 在基线和三个月后测量了血清前素,血清皮质醇,C反应蛋白 (CRP),红细胞沉积率 (ESR),总白细胞计数和差异白细胞计数.
- 评估精神病理学和全球功能.
主要成果:
- 在超过四分之三的患者中,观察到心理病理和整体功能显著改善.
- 改善的患者显示,白细胞总数,绝对中性粒细胞数和中性粒细胞与淋巴细胞的比率显著降低.
- 未经治疗的疾病持续时间与ESR正相关 (P = .042;r = 0.401).
结论:
- 在从未服用过药物的ATPD患者中存在炎症生物标志物的升高.
- 抗精神病治疗导致这些炎症标志物的减少.
- 研究结果表明,炎症在ATPD的发病过程中可能起作用.
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