相关实验视频
Updated: Apr 12, 2026

08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
10.9K
革命性的NIR激活纳米粒子:精确控制的释放和有针对性的3D癌细胞破坏
Vy Anh Tran1, Nguyen Huy Hung2,3, Thu Thao Thi Vo4
1Deparment of Material Science, Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University Ho Chi Minh City 700000 Vietnam tavy@ntt.edu.vn.
RSC advances
|February 17, 2025
概括
这项研究介绍了带有dieckol的中孔纳米粒子 (MSN),用于向癌症治疗. 近红外 (NIR) 光精确地控制药物释放,提高疗效和减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 控制药物输送对于有效的癌症治疗至关重要,最大限度地减少副作用.
- 半孔纳米粒子 (MSN) 为药物封装和有针对性的输送提供了一个多功能平台.
- 像迪科尔这样的天然化合物显示出抗癌潜力,但需要高效的输送系统.
研究的目的:
- 开发一个创新的,NIR响应的半孔纳米粒子 (MSN) 平台,用于向的癌症药物输送.
- 为了使MSN与dieckol (Di) 和光有机合物具有功能,用于化疗-光热效应.
- 为了实现精确的,按需的药物释放,通过近红外 (NIR) 辐射激活.
主要方法:
- 用迪科尔 (Di) 和光有机合物对MSN进行功能化.
- 在各种pH条件下和在NIR照射下研究药物释放特征.
- 在癌细胞系 (SH-SY5Y,B16-F10) 和健康细胞 (HEK-293) 的体外细胞毒性测定.
- 使用癌症球体模拟体内条件的3D细胞活力测试.
主要成果:
- 开发的纳米粒子对NIR刺激表现出敏感性,使药物释放得到控制.
- 药物释放在不同的pH水平上是稳定的,但在NIR暴露时有选择地加速.
- 观察到显著的,剂量依赖的癌细胞生长抑制,对健康细胞的毒性最小.
- 3D球体测试证实了纳米粒子强大的抗癌潜力.
结论:
- 开发的MSN平台为选择性和有效的癌症治疗提供了一个有希望的方法.
- 从功能化MSN中释放NIR触发的按需药物可以提高治疗效率.
- 协同化学-光热效应和线粒体向有助于该平台强大的抗癌活性.
相关概念视频
Targeted Cancer Therapies
9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.2K
Modified-Release Drug Delivery Systems: Site-Targeted
130
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
130
Site-Targeted Drug Delivery Systems: Polymeric Carriers
125
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
125

