RPL39与肺动脉高血压的性别差异有关
Haixia Wang1,2, Ling Li2, Guangyuan Zhou3
1National Health Commission Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (Co-Construction), Department of Scientific Research, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China.
Canadian respiratory journal
|February 17, 2025
概括
肺动脉高血压 (PAH) 的性别差异与男性的巨细胞增加有关. 抑制核糖体蛋白L39 (RPL39) 减少了巨细胞的增殖和PAH的性别差异.
科学领域:
- 心血管科学 心血管科学
- 细胞生物学 细胞生物学
- 肺部医学 肺部医学
背景情况:
- 肺动脉高血压 (PAH) 是一种具有复杂原因的严重心血管疾病.
- 观察到的PAH易感性和生存率的性别差异缺乏单细胞水平的解释.
- 细胞组成的变化与PAH的发病有关.
研究的目的:
- 为了研究肺动脉高血压中单细胞水平的性别差异.
- 确定特定的细胞类型和途径,有助于PAH观察到的性别差异.
- 探索潜在的治疗目标,以减轻PAH的性别差异.
主要方法:
- 对单细胞RNA测序数据集的分析 (GSE169471,GSE228644).
- 在男性和女性PAH肺组织中细胞类型比率的比较分析.
- 在关键细胞群中识别和功能分析差异表达基因 (DEGs).
主要成果:
- 与女性相比,男性PAH肺组织中发现了细胞类型比率的显著变化.
- 巨细胞,特别是M1巨细胞,在男性PAH样本中发现的比例明显高 (增加7倍).
- 巨细胞中差异表达的基因在与细胞增殖相关的核糖体通路中被丰富;抑制核糖体蛋白L39 (RPL39) 减少了巨细胞增殖和PAH性别差异.
结论:
- 由核糖体通路活动驱动的巨细胞增殖可能是肺动脉高血压的性别差异的基础.
- 向巨细胞中的核糖体通路为PAH性别差异提供了潜在的治疗策略.
- 这项研究为推动PAH性别差异的细胞机制提供了新的见解.
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