在不同持续时间的T2DM患者中,通过常规CMR及其决定因素评估的血液动力学力量受损,患者的LV功能正常,心肌应变为正常
Guozhu Shao1,2,3, Yukun Cao1,2,3, Yue Cui1,2,3
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in cardiovascular medicine
|February 17, 2025
概括
血动力学力 (HDFs) 在射出分数或应变明显之前,在2型糖尿病 (T2DM) 患者中显示出亚临床心肌功能障碍的早期指标. HDF分析与糖尿病持续时间和晚期加多增强相关,为T2DM中心脏健康提供了新的见解.
科学领域:
- 心血管成像 - 心血管成像
- 医学物理 医学物理
- 糖尿病学 糖尿病学
背景情况:
- 在2型糖尿病 (T2DM) 中早期发现亚临床心肌功能障碍对于预防明显的左心室喷射率 (LVEF) 和心肌应变至关重要.
- 常规的心脏磁共振 (CMR) 成像对于评估T2DM患者的心脏功能至关重要.
研究的目的:
- 在T2DM患者的Cine CMR图像上使用数学模型对血动力学力 (HDF) 进行定量评估.
- 调查HDF与晚期加多增强 (LGE) 和糖尿病持续时间的相关性.
主要方法:
- 招募了63名T2DM患者和50名健康志愿者进行对比增强的CMR.
- 根据糖尿病持续时间 (<5,5-10,≥10年) 将T2DM患者分为早期,中期和晚期.
- 测量了左心室 (LV) 变形参数 (LVGCS,LVGRS,LVGLS) 和 HDF 参数 (纵向 A-B,横向 L-S RMS).
主要成果:
- 与对照组相比,T2DM患者的HDF强度 (RMS) L-S (%) 显着更高 (p < 0.001),LV功能或菌株没有显著差异.
- 晚期T2DM患者的LVGLS显著下降,而HDF强度 (RMS) L-S (%) 与早期患者相比增加.
- HDF强度 (RMS) L-S (%) 和A-B (%) 独立地与LGE程度相关 (p=0.001,p=0.006) 和HDF强度 (RMS) L-S (%) 与胰岛素治疗相关 (p=0.013).
结论:
- HDF分析为LVEF和应变之前的亚临床心肌功能障碍提供了宝贵的见解,可能作为早期标志物.
- 在T2DM患者中,随着糖尿病持续时间的增加,LVGLS损伤的进展.
- HDF参数与LGE程度相关,横向的HDF成分随着糖尿病持续时间的增加而增加.
更多相关视频
相关概念视频
Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...


