在状细胞疾病中输血和交换输血的指示:单个中心的经验
Essa Alsharari1, Abdulelah Al Enazi1, Ehab Hanafy2
1Pediatric Department, King Salman Armed Forces Hospital, Tabuk, SAU.
Cureus
|February 17, 2025
概括
输血对于治疗儿科状细胞病 (SCD),特别是急性胸部综合征 (ACS) 和中风预防至关重要. 简单的输血有效地治疗了ACS,但需要改进对基尿素和标准化指南的遵守.
科学领域:
- 血液学 血液学 血液学
- 儿科医学 儿科医学
- 输血医学 输血医学
背景情况:
- 状细胞病 (SCD) 是一种常见的遗传性血液疾病,导致贫血和器官损伤.
- 输血对于治疗中风和急性胸部综合征 (ACS) 等SCD并发症至关重要.
- 优化输血策略是必要的,因为风险,如合免疫和铁过载.
研究的目的:
- 确定儿童SCD患者常见的输血和交换输血指示.
- 分析萨勒曼国王武装部队医院 (KSAFH) 的输血模式和结果.
- 为改善儿科SCD的输血管理提供信息.
主要方法:
- 在KSAFH对99名儿科SCD患者 (年龄1-14岁) 的观测横截面研究.
- 从电子医疗记录中追溯收集数据.
- 描述性统计和千平方/ANOVA测试,以分析输血指示和结果.
主要成果:
- 急性胸部综合征 (ACS) 是最常见的输血指示 (32.3%),其次是溶血危机 (18.2%) 和中风预防 (11.1%).
- 在31.3%的严重并发症患者中,使用了交换输血.
- 简单的输血在超过75%的ACS病例中是有效的;不良反应很少发生 (4%).
结论:
- 输血对于管理儿科SCD,特别是ACS和中风预防至关重要.
- 简单的输血在ACS中显示出有效性,这表明潜在的少侵入性治疗方法.
- 高基尿素不合规性和输血实践的变化需要标准化的指导方针和患者教育.
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