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血清高级糖化终产品作为2型DKD患者预后中的假定生物标志物

Ze-Hou Wang^1,2, Zong-Jin Zhang³, Yue-Fen Wang⁴

¹Department of Nephrology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China.

Frontiers in physiology

|February 17, 2025

概括

一个新的生物标志物,纠正的对数转换先进糖化终产物 (lgAGEs),在预测2型糖尿病患者的不良结局方面显示出希望. 将这种生物标志物与尿中的白蛋白与肌素比率 (UACR) 结合起来,可以改善糖尿病病的风险评估.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
生物标志物发现发现

背景情况:

先进的糖化终产品 (AGEs) 在糖尿病病 (DKD) 中起着关键作用.
在DKD中AGE的预测值需要进一步调查.
通过调整血清白蛋白 (ALB) 的AGE水平,开发了一种新的生物标志物,即纠正的对数转换AGE (lgAGEs).

研究的目的:

引入和评估纠正的lgAGEs作为预测2型DKD (T2DKD) 患者不良结局的新生物标志物.
评估纠正的lgAGE与脏结果的独立关联.
为了确定纠正的lgAGEs的预测性能,单独和与UACR结合.

主要方法:

对196名T2DKD患者进行了前性队列研究,并进行了纵向随访.
血清AGEs经过日志转换并为ALB进行调整,以获得更正的lgAGEs.
考克斯的比例危险模型和卡普兰-梅尔分析评估了纠正的lgAGE水平与脏结果之间的关联.
接收器操作特征 (ROC) 曲线分析评估了经过校正的lgAGE和UACR的预测性能.

主要成果:

高水平的正确的lgAGE与不良的结局独立相关 (HR,3.252;p=0.003).
高校正的lgAGEs患者的中位生存时间显著缩短 (12个月与50个月相比).
结合UACR和纠正的lgAGEs改善了预测特异性 (75.6%) 和保持敏感性 (70.7%),AUC为0.764.

结论:

纠正的lgAGEs是预测T2DKD中脏不良结果的新型独立生物标志物.
结合UACR和纠正的lgAGE,通过提高特异性来增强风险分层.
这种综合方法显示了早期识别高风险T2DKD患者的潜力,需要在更大的人群中进行验证.

关键词:

先进的糖化最终产品 (AGEs)正确的LGAGEs已经得到了修正.糖尿病病 (DKD) 是一种糖尿病性病.的预后的预后尿中的白蛋白与肌素的比率 (UACR)

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