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Updated: Apr 8, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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作为尿素酶抑制剂的基于库马林的新型酸-1,2,3-二醇衍生物:合成,体外评估和分子动力学模拟研究

Hassan Sepehrmansourie1, Mohammad Azimi2, Ahmad Ebadi2,3

  • 1Faculty of Converging Science and Technologies, University of Qom, Qom, Iran.

Heliyon
|February 17, 2025
PubMed
概括

基于库马林的新型化合物显示出强大的尿酶抑制,为像H. pylori这样的尿溶性细菌感染的现有治疗方法提供了一个有希望的替代方案. 这些新衍生物表现出强烈的抗尿酶活性和有利的相互作用机制,为新药开发铺平了道路.

关键词:
1,2,3-三醇是一种乙烯基化化.库马林是一种素.分子对接是分子对接.分子动力学模拟的模拟.抑制尿酶的抑制作用

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