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基线F-FDG PET/CT参数预测免疫治疗在非小细胞肺癌中的疗效

Lu Zheng^1,2, Yanzhu Bian^1,2, Yujing Hu¹

¹Department of Nuclear Medicine, Hebei General Hospital, Shijiazhuang, China.

Frontiers in medicine

|February 17, 2025

概括

这项研究确定了接受免疫检查点抑制剂 (ICI) 的非小细胞肺癌 (NSCLC) 患者生存的关键预测因素. 从未吸烟,初级病变SUVmax,MTVp和TLGp较低的患者,以及年龄较小的患者,在ICI治疗中表现更好.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
免疫治疗是一种免疫疗法.

背景情况:

非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
免疫检查点抑制剂 (ICI) 已经彻底改变了NSCLC的治疗方法,但预测患者的反应仍然是一个挑战.
阳位子发射断层扫描/计算机断层扫描 (PET/CT) 提供了对瘤特征有价值的见解.

研究的目的:

分析用ICI治疗的NSCLC患者的PET/CT成像和临床数据.
为了确定与改善生存率相关的患者特征.
开发一种ICI治疗疗效的预测模型.

主要方法:

对155名NSCLC患者的基线PET/CT扫描和临床数据的回顾性分析.
卡普兰-梅尔生存分析以比较无进展生存 (PFS) 和整体生存 (OS).
多变量考克斯回归以确定ICI组中PFS和OS的独立预测因子.

主要成果:

在ICI和非ICI组之间观察到PFS和OS的显著差异.
在ICI组中,PFS和OS的独立预测因素包括吸烟史,初级病变SUVmax,代谢瘤体积 (MTVp) 和总病变糖解 (TLGp).
年龄也是OS的独立预测因素.

结论:

吸烟史,SUVmax,MTVp和TLGp预测ICI治疗的NSCLC患者的PFS和OS.
年龄是OS的额外预测因素.
从未吸烟的患者,SUVmax ≤19.2,MTVp ≤20.745cm3,TLGp ≤158.62g,年龄 ≤60岁,可能会从ICI治疗中获益更多.

关键词:

聚乙烯/聚乙烯/聚乙烯这是一辆SUV,SUVSUV.免疫检查点抑制剂免疫检查点抑制剂非小细胞肺癌的肺癌.预后预后预后

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