肺结核患者患有糖尿病多药耐药性的危险因素
Lianpeng Wu1,2, Na Chen1,2, Dandan Xia1,2
1Department of Clinical Laboratory Medicine, The Ding Li Clinical College of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou, Zhejiang, China.
Frontiers in medicine
|February 17, 2025
概括
吸烟,HbA1c升高和先前的结核病治疗是患有肺结核 (PTB) 和糖尿病 (DM) 患者多抗药结核病 (MDR-TB) 的关键危险因素. 识别这些因素有助于早期诊断和管理MDR-TB.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
背景情况:
- 肺结核 (PTB) 和糖尿病 (DM) 经常同时发生,增加了患者的脆弱性.
- 耐多药结核病 (MDR-TB) 构成了全球重大卫生挑战,特别是在同时感染的人群中.
- 了解PTB/DM患者中MDR-TB的风险因素对于有效的控制策略至关重要.
研究的目的:
- 在被诊断患有肺结核 (PTB) 和糖尿病 (DM) 的患者中调查与多药性耐药性 (MDR) 相关的独立风险因素.
- 分析患有或没有结核病治疗史的患者的风险因素.
主要方法:
- 进行了一项回顾性研究,涉及318名PTB和DM患者.
- 使用多变量逻辑回归和ROC曲线分析来确定MDR-TB的独立风险因素.
- 收集的数据包括人口统计,临床症状,实验室结果和治疗史.
主要成果:
- 在整体队列中,MDR-TB的独立预测因素包括先前的结核病治疗,吸烟和升高的血红蛋白A1c (HbA1c).
- 在没有先前结核病治疗的患者中,吸烟和HbA1c是显著的风险因素 (AUC=0.771).
- 对于以前接受过结核病治疗的患者,住所和肺腔被确定为预测因素 (AUC=0.802).
结论:
- 吸烟史,HbA1c水平,居住地和肺腔是PTB和DM患者中MDR的重要危险因素.
- 早期识别这些风险因素可以促进及时诊断和治疗MDR-TB.
- 这些发现强调了对高风险PTB/DM人群进行有针对性的干预的必要性.
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