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¹⁸F-氧葡萄糖正子发射断层扫描-计算机断层扫描用于预测乳腺癌患者对新辅助化疗剂的病理完整反应

Chengchun Ge¹, Lukai Shi¹, Zhonghua Tan¹

¹Department of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong, China.

|February 17, 2025

概括

一种使用18F-FDG PET/CT代谢参数的新型诺米图准确地预测了乳腺癌 (BC) 新辅助化疗 (NACT) 的病理完整反应 (pCR). 这有助于个性化治疗BC患者,改善治疗结果.

科学领域:

在瘤学瘤学.
核医学就是核医学.
无线电学 (Radiomics) 是一种辐射学.

背景情况:

准确预测乳腺癌 (BC) 中新辅助化疗 (NACT) 的病理完整反应 (pCR) 是至关重要的,但具有挑战性.
目前的成像模型努力整合代谢参数,以提高预测准确度.
这项研究的重点是利用18F-化氧葡萄糖 (FDG) 定子发射断层扫描/计算机断层扫描 (PET/CT) 参数来改善PCR预测.

研究的目的:

开发和验证一个包含18F-FDG PET/CT参数 (SUVmax,MTV,TLG) 的名录,用于预测BC.的PCR到NACT.
评估代谢性瘤负担和活动参数在预测pCR的集体能力.
确定改善BC治疗疗效评估的关键预测因素.

主要方法:

在NACT之前和之后对95名BC患者进行18F-FDG PET/CT的回顾性分析.
根据病理结果分类为pCR (n=46) 和非pCR (n=49) 组.
使用培训和验证队列进行后勤回归和名ogram构建/验证,使用ROC评估性能,校准和决策曲线分析.

主要成果:

与非pCR组相比,pCR组显示出较小的瘤,较低的Ki-67,较少的淋巴结,以及较高的HER2+状态.
在治疗前和治疗后的SUVmax,MTV和TLG在pCR组显着较低,并在NACT后显著下降.
SUVmax,MTV,TLG和分子亚型是非pCR的独立预测指标;该名图实现了0.9003 (训练) 和0.9363 (验证) 的AUC.

结论:

18F-FDG PET/CT在临床上有价值,用于预测BC的PCR到NACT.
开发的整合新陈代谢参数的诺姆图准确预测治疗疗效.
这有助于早期识别不响应者,从而实现个性化治疗调整和优化资源配置.

关键词:

18F-氧葡萄糖正子发射断层扫描/计算机断层扫描 (18F-FDG PET/CT)乳腺癌 (BC) 是一种癌症.新辅助化疗 (NACT) 的使用.病理完整反应 (pCR) 是一种病理的完整反应.预测模型预测模型

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