非向的代谢分析揭示了四种双细菌菌株的代谢变异性,用于益生菌的发展
Kailong Liu1,2,3,4, Guoqiang Yao1,2,3,4, Zhan Yang1,2,3,4
1Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Frontiers in microbiology
|February 17, 2025
概括
这项研究揭示了四种Bifidobacterium菌株的不同代谢概况,突出了氨基酸,胆酸和维生素代谢的变化. 这些发现对于开发基于特定细菌功能的向益生菌配方至关重要.
科学领域:
- 微生物学和肠道微生物组研究
- 代谢学和系统生物学
- 益生菌和功能性食品的发展
背景情况:
- 双杆菌物种是人类肠道微生物群的重要组成部分,影响宿主健康.
- 菌株特定的Bifidobacterium代谢功能可以导致不同的健康结果.
- 了解这些代谢差异是优化益生菌应用的关键.
研究的目的:
- 为了比较分析四个选定的Bifidobacterium菌株的细胞内代谢概况.
- 为了确定菌株特定的代谢活动和途径.
- 为开发有针对性的益生菌配方提供见解.
主要方法:
- 培养了四种Bifidobacterium菌株:B. animalis亚种. 乳糖BB-69,Bbm-19,B. brevis BX-18,以及B. longum亚种. 这两种类型的乳糖分类. 婴儿类动物 B8762.
- 不针对性的比较代谢分析,以评估细胞内代谢物概况.
- 针对特定代谢物的有针对性的分析,以确认菌株特定的途径.
主要成果:
- 鉴定了1340种代谢物,揭示了跨菌株代谢特征的显著变化.
- B. animalis 亚种 动物类 乳糖Bbm-19显示出更高的氨基酸生物合成活性.
- B. animalis 亚种 动物类 乳酸BB-69在二次胆酸和α-烯酸代谢中表现出色.
- B.长子种.长子种. infantis B8762在PAH降解,维生素代谢和银河糖代谢方面表现出增强的活性.
- B. brevis BX-18在托代谢和粉/葡萄糖酸盐相互转换中更活跃.
结论:
- 系统地阐明四种Bifidobacterium菌株在非目标代谢水平上的代谢特征差异.
- 证明菌株特定的代谢能力,包括氨基酸,胆酸和维生素代谢.
- 对Bifidobacterium菌株的代谢特征有价值的见解,用于有针对性的益生菌开发.
相关概念视频
Self-Evaluation: Self-Enhancement and Self-Verification
4.7K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
4.7K
General State of Stress
916
The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
916
Ethnic Identity within a Larger Culture
412
Adolescents from ethnic minority backgrounds face a multifaceted journey in forming their identities, shaped by the intersections of cultural expectations and personal exploration. For these adolescents, identity formation involves not only typical developmental challenges but also navigating the perceptions and attitudes of the majority culture. As they grow, adolescents in ethnic minority groups often become increasingly aware of stereotypes, social biases, and discrimination, all of which...
412
Introduction to Stress and Lifestyle
861
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
861
Psychological Responses to Stress
976
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
976
Stress and Mental Health
1.7K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.7K


