血D-D和CRP作为严重肺炎老年患者死亡率的预测指标
Yaping Yu1, Qi Ren1, Hongyan Jin1
1Intensive Care Unit, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine Hangzhou 310000, Zhejiang, China.
American journal of translational research
|February 17, 2025
概括
升高的D-二聚合物 (D-D) 和C-反应蛋白 (CRP) 水平预测严重肺炎的老年患者的死亡风险更高. 这些生物标志物可以帮助临床决策,以获得更好的患者结果.
科学领域:
- 老年医学 老年医学
- 关键护理医学 关键护理医学
- 临床生物化学 临床生物化学
背景情况:
- 严重的肺炎具有显著的死亡风险,特别是在老年患者中.
- 确定可靠的预后标志物对于有效的临床管理和资源分配至关重要.
研究的目的:
- 评估血D-二聚合物 (D-D) 和C-反应蛋白 (CRP) 水平对被诊断患有严重肺炎的老年人死亡风险的预测能力.
- 为了确定D-D和CRP是否可以在这个脆弱的患者群体中作为预后指标.
主要方法:
- 对119名患有严重肺炎的老年患者的临床数据进行了回顾性分析.
- 根据结果,患者被分为生存和死亡组.
- 分组之间比较了血D-D和CRP水平,并使用统计分析评估了它们的预后值,包括多变量Cox回归.
主要成果:
- 与生存组相比,死亡组的患者表现出明显更高的DD和CRP水平 (P<0.05).
- D-二次体的AUC为0.601 (灵敏度为55.56%,特异性为63.83%),而CRP的AUC为0.624 (灵敏度为72.22%,特异性为48.94%).
- 提升的D-D和CRP水平被确定为严重肺炎死亡率的独立预后因素.
结论:
- 血D-D和CRP水平的增加与严重肺炎的老年患者的预后较差和死亡风险较高有关.
- 这些发现表明,D-D和CRP是有价值的生物标志物,可以帮助临床医生做出明智的决策,并为严重肺炎的老年患者量身定制管理策略.
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