在患有2型糖尿病的老年患者中,糖尿病外围神经病变和甲状腺激素敏感性之间的相关性
Si-Jia Fei1, Jing-Yi Luo1, Wei-Hao Wang1
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
在患有2型糖尿病的老年患者中,自由三甲状腺素与自由甲状腺素 (FT3/FT4) 的比率较低与糖尿病外围神经病变 (DPN) 的发病率较高有关. 这种FT3/FT4比率可以有效地预测该人群中的DPN.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病周围神经病变 (DPN) 是2型糖尿病 (T2DM) 的常见并发症,严重影响患者的生活质量和医疗费用.
- 甲状腺激素越来越多地被认为是它们在糖尿病并发症中的作用,特别是在老年T2DM患者中,但它们与DPN的具体联系尚未得到充分证实.
研究的目的:
- 调查甲状腺激素敏感性,特别是FT3/FT4比率与T2DM老年患者中DPN的存在之间的联系.
- 评估FT3/FT4比率在预测DPN时的诊断值.
主要方法:
- 分析了256名老年T2DM患者的队列,使用与年龄,性别和糖尿病持续时间相匹配的倾向得分与对照进行了匹配.
- 计算了甲状腺激素的敏感性,并使用临床数据评估了与DPN的相关性.
- 采用随机森林模型来确定DPN的自由三甲状腺素/自由甲状腺素 (FT3/FT4) 比率的预测性能.
主要成果:
- 与没有DPN的患者相比,DPN患者的FT3/FT4比率明显较低.
- 较低的FT3/FT4比率与较差的血糖控制 (HbA1c,禁食葡萄糖),降低的神经传导速度和较低的皮肤电导率相关.
- 后勤回归显示,较高的FT3/FT4比率与更好的皮肤电化学导电性和外围神经感觉幅度有关,表明神经功能更好.
结论:
- 在患有T2DM的轻甲状腺老年患者中,FT3/FT4比率的降低与DPN发病率的增加显著相关,影响大和小神经纤维.
- FT3/FT4比率显示出在这个患者群体中作为DPN的有效和独立预测因子的潜力.
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