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转录组和单细胞分析糖尿病病的机制

Ying Zhou1, Xiao Fang2, Lin-Jing Huang1,3,4,5,6

  • 1Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.

World journal of diabetes
|February 17, 2025
PubMed
概括

糖尿病病 (DKD) 涉及NLRP3炎症酶. 研究人员确定SIRT2和CASP1是关键生物标志物,为DKD提供了潜在的新疗法.

关键词:
卡斯帕斯1 1 的情况.糖尿病脏疾病 糖尿病脏疾病类似NOD的受体热蛋白域相关蛋白3单细胞RNA测序分析分析塞尔图因 2 2 在

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Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...