在患有后COVID疾病的患者中,大脑氧气提取率升高
Peiying Liu1, Thomas Ernst1,2, Huajun Liang1
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
概括
后COVID-19条件 (神经-PCC) 显示大脑氧气提取分数 (OEF) 发生变化,特别是在住院患者中. 这种OEF变化与运动速度减慢有关,这表明OEF是神经-PCC的关键标志物.
科学领域:
- 神经学 神经学
- 心血管科学 心血管科学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19条件 (神经-PCC) 中的神经症状可能源于由于SARS-CoV-2感染而导致大脑微循环受损和大脑氧气稳定性改变.
- 研究大脑的氧气供应和消耗平衡对于理解神经PCC至关重要.
研究的目的:
- 在经历神经PCC的患者中调查氧气提取分数 (OEF).
- 探索神经PCC患者OEF和神经行为缺陷之间的关系.
主要方法:
- 利用TRUST MRI量化全球OEF在25名神经PCC患者 (8名住院患者,17名非住院患者) 和59名健康对照患者中.
- 组间对OEF进行比较,考虑年龄和性别.
- 在神经PCC参与者中评估了OEF和神经行为测量之间的关联.
主要成果:
- 在三组中观察到OEF的显著差异 (p=0.046).
- 以前住院的神经PCC患者的OEF (42.40±5.40%) 与未感染的对照 (37.70±5.09%) 和未住院的神经PCC患者 (37.02±5.05%) 相比显著更高.
- 在神经PCC患者中,OEF与运动器官功能有显著的相关性,特别是4米的步行速度 (β=-0.03,r=0.34,p=0.003).
结论:
- 神经PCC与大脑OEF的改变有关.
- 神经性PCC患者的OEF升高,特别是之前住院的患者,表明潜在的脑氧化失衡.
- OEF 作为神经PCC研究的有前途的生物标志物,可能与功能缺陷 (如流动性减弱) 相相关.
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