脂质组数据的预测值,用于2型糖尿病患者的宏观血管并发症发展,并患有并发性甲状腺功能障碍
Mariya Marushchak1, Inna Krynytska1, Olena Gashynska2
1Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Acta clinica Croatica
|February 17, 2025
概括
血清脂质概况预测2型糖尿病 (T2DM) 患者的宏血管并发症,特别是那些患有甲状腺疾病的患者,如甲状腺功能低下症 (HT) 和扩散无毒 (DNTG). 胆固醇和甘油三的特定切断值可以识别高风险个体.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 临床生物化学 临床生物化学
背景情况:
- 2型糖尿病 (T2DM) 显著增加了宏血管并发症 (MVC) 的风险.
- 并发性甲状腺功能障碍,包括甲状腺功能低下症 (HT) 和扩散性无毒 (DNTG),可以进一步改变T2DM患者的心血管风险.
- 在患有这些特定甲状腺共发病的T2DM患者中,常规脂质面板参数的预后值需要详细评估.
研究的目的:
- 评估血清脂质资料对T2DM患者MVC发展的预测能力.
- 确定特定的脂质切断值,表明T2DM患者有或没有并发性甲状腺功能障碍 (HT,DNTG或两者) 的MVC风险增加.
- 根据MVC发育风险对T2DM甲状腺功能障碍患者进行分层.
主要方法:
- 分析了596名T2DM住院患者的队列.
- 测量了血清脂质参数,包括总胆固醇 (TC),甘油三 (TG),高密度脂蛋白胆固醇 (HDL-C),低密度脂蛋白胆固醇 (LDL-C),非HDL胆固醇 (非HDL-C) 和残留胆固醇 (RC).
- 采用接收器操作特征 (ROC) 分析来确定预后显著的脂质值,并为MVC风险分层建立最佳切断点.
主要成果:
- 特定的预后切断值TC,TG,LDL-C和非HDL-C被确定为T2DM患者与并发性HT.
- 对于同伴DNTG的T2DM患者,已确定TC,TG,LDL-C和非HDL-C的截止值.
- 对于患有HT和DNTG的T2DM患者,确定了TC,TG,LDL-C,非HDL-C和RC的特定切断值,表明他们的MVC风险增加.
结论:
- 血清中TC,TG,LDL-C和非HDL-C水平是T2DM并发性甲状腺功能低下症患者中MVC的有价值的预测指标.
- 血清脂质谱,包括RC,可以有效地分层T2DM患者与共存的扩散性非毒性囊和甲状腺功能低下症基于他们的宏血管并发症风险.
- 这些发现支持使用脂质面板数据用于T2DM甲状腺功能障碍患者的风险评估和管理策略.
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