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Yishenyangsui颗粒用于退行性宫骨髓病变:一个随机,双盲,安慰剂对照试验,长期随访
He Yin1, Xin Chen1, Zhiwei Liu1,2
1Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in pharmacology
|February 17, 2025
概括
伊申扬苏伊颗粒有效治疗轻度至中度退行性宫肌病,改善JOA分数并降低重复治疗率. 参与者体验到更好的运动和感官功能,带来持续的长期益处.
科学领域:
- 神经学 神经学
- 综合医学是一个整体医学.
- 临床药理学 临床药理学
背景情况:
- 退行性宫肌病 (DCM) 是一种进展性神经疾病,影响脊髓功能.
- 目前DCM的治疗选择存在局限性,需要探索替代疗法.
- 伊申阳水颗粒是一种传统中医药配方,对神经系统疾病具有潜在的治疗益处.
研究的目的:
- 评估Yishenyangsui颗粒在治疗轻度至中度退行性宫肌病症患者中的疗效和安全性.
- 评估Yishenyangsui颗粒对神经功能,患者报告的结果和长期疾病进展的影响.
- 为了在随机对照试验中比较Yishenyangsui颗粒与安慰剂的有效性.
主要方法:
- 一个随机,双盲,安慰剂控制的试验,涉及三个中心152名参与者.
- 参与者接受了Yishenyangsui颗粒或安慰剂32周.
- 评估包括日本整形医学协会 (JOA) 评分,部残疾指数 (NDI) 和患者报告的长期随访结果.
主要成果:
- 与安慰剂相比,Yishenyangsui颗粒组在第8周观察到JOA得分的显著改善 (1.47与0.43;P<0.001).
- 在Yishenyangsui颗粒组 (P <0.05) 中,在运动功能,感官功能,阅读能力和娱乐领域的优异改善被注意到.
- 在Yishenyangsui颗粒组观察到明显较低的再处理率 (43.10%与68.97%相比;P = 0.033),表明进一步干预的需求减少.
结论:
- 伊申扬苏伊颗粒在治疗轻度至中度退行性宫肌病方面表现出显著的疗效.
- 治疗导致神经功能显著改善,并减少了重新治疗的需要.
- 这些发现支持使用Yishenyangsui颗粒作为DCM患者的有价值的治疗选择,提供更好的长期结果.
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