大麻素受体2选择性激动剂通过调节Treg和Th17细胞之间的平衡来改善辅助剂诱导的关节炎

Na Tian1, Cui Yang2, Yu Du1

  • 1Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in pharmacology
|February 17, 2025
PubMed
概括

作为CB2激动剂的HU-308在风湿性关节炎模型中有效降低了炎症和关节损伤. 它通过促进调节性T细胞和抑制炎症性T细胞恢复了免疫平衡,显示了自身免疫性疾病治疗的潜力.

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