在斯特奇-韦伯综合征中治疗扩散性胆道血管瘤的肠内阿弗利伯塞普特
Georges El Mollayess1, Karim Sleiman1,2, Riwa Ibrahim1
1Department of Ophthalmology, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.
Middle East African journal of ophthalmology
|February 17, 2025
概括
在一个患有Sturge-Weber综合征 (SWS) 的患者中,Intravitreal aflibercept成功治疗了黄斑胀和胆道新血管化. 这种方法为患有这些特定眼部并发症的SWS患者的视觉改善提供了有希望的选择.
科学领域:
- 眼科医生 眼科 眼科
- 医学遗传学 医学遗传学
背景情况:
- 斯特格-韦伯综合征 (SWS) 是一种罕见的先天性疾病,其特征是独特的血管形.
- 在SWS的眼部并发症可以包括玻璃眼睛瘤,胸腔血管瘤和二次视力障碍.
研究的目的:
- 报告在SWS患者中成功使用内阿弗利塞普特,患者呈现斑点和胆道新血管化.
- 为了评估aflibercept治疗SWS这些特定的眼部表现的疗效和持久性.
主要方法:
- 一名16岁的女性患有SWS和视力下降,接受了检查和多式成像.
- 治疗包括每月三次静脉内注射aflibercept.
- 在治疗后和随访期间评估视力敏度和黄斑.
主要成果:
- 患者在受影响的眼睛的视力敏度为20/100.
- 多式成像揭示了扩散性胆道血管瘤,胆道新血管化和黄斑.
- 在aflibercept治疗后,视力改善了4条线,黄斑完全消失.
- 黄斑的解消持续了治疗后4个月.
结论:
- 这是首个成功治疗黄斑和冠状腺新血管化,以扩散性冠状腺瘤为次要的SWS的afflicept报告的案例.
- 建议在出现这些眼部并发症的SWS患者早期考虑使用抗血管内皮生长因子 (anti-VEGF) 治疗,例如aflibercept.
相关概念视频
01:28Angle Closure Glaucoma: Treatment
430
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
430
01:27Open Angle Glaucoma: Treatment
384
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
384