身体圆度指数与女性不孕症之间的关联:来自NHANES的横截面研究
Ming Liu1, Yifang Zhang1, Jian Liu1
1Department of Gynecology and Oncology, First Affiliated Hospital, Bengbu Medical University, Bengbu, Anhui, China.
Frontiers in endocrinology
|February 17, 2025
概括
较高的身体圆度指数 (BRI) 与美国女性不孕症风险增加有关. BRI是比身体质量指数 (BMI) 更好的不孕症预测指标,这表明与内脏脂肪有更强的关联.
科学领域:
- 生殖健康 生殖健康
- 肥胖问题研究研究
- 生物统计学 生物统计学
背景情况:
- 不孕症与肥胖密切相关,内脏脂肪积累是一个关键问题.
- 身体圆度指数 (BRI) 比身体质量指数 (BMI) 更准确地衡量内脏脂肪.
- 关于内脏脂肪与不孕不育之间的关系的现有研究是有限的和相互矛盾的.
研究的目的:
- 调查BRI与成人女性不孕症之间的相关性.
- 为了比较BRI与BMI对不孕症风险的预测能力.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多重物流回归,平滑曲线拟合,子组分析和相互作用测试.
- 进行了接收器操作曲线 (ROC) 分析,以评估预测准确性 (AUC,灵敏度,特异性).
主要成果:
- 分析了1463名女性 (年龄在20-45岁) 的数据,其中172名被确定为不育.
- 每增加1个单位的BRI与19%更高的不孕症风险相关 (OR = 1.19,95% CI 1.05,1.34).
- 与BMI (BRI AUC = 0.5773与BMI AUC = 0.5681) 相比,BRI表现出更好的不孕症风险预测能力.
结论:
- 在美国成年女性中,高BRI和不孕症之间存在积极的关联.
- BRI与不孕症风险的关联比BMI更强,强调其作为内脏脂肪指标的潜力.
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