在患有扩散型大B细胞淋巴瘤的患者中,可溶性编程细胞死亡联体-1的预后和临床病理学作用:元分析

在患有扩散型大B细胞淋巴瘤的患者中,可溶性编程细胞死亡联体-1的预后和临床病理学作用:元分析

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Hongbin Lu¹, Lulu Luo¹, Jie Mi¹

¹Department of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, China.

Frontiers in oncology

|February 17, 2025

概括

升的可溶性编程死亡蛋白联体-1 (sPD-L1) 表明扩散型大B细胞淋巴瘤 (DLBCL) 患者的预后较差,与总生存率和无进展生存率的降低相关. 较高的sPD-L1与更具侵略性的疾病特征有关.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

在扩散性大B细胞淋巴瘤 (DLBCL) 的预后中,可溶性编程死亡蛋白联体-1 (sPD-L1) 的重要性仍在争论中.
之前的分析对sPD-L1的预测价值产生了相互矛盾的结果.

研究的目的:

研究DLBCL.患者溶性PD-L1 (sPD-L1) 表达的预后影响.
澄清sPD-L1水平与患者生存结果之间的关联.

主要方法:

进行了一项元分析,搜索主要的科学数据库 (Web of Science,PubMed,Embase,CNKI) 到2024年8月14日.
聚合危险比率 (HRs) 和95%置信区间 (CI) 计算了整体存活 (OS) 和无进展存活 (PFS).
几率比率 (ORs) 和95%CI被用来探索sPD-L1和临床病理因素之间的关联.

主要成果:

包括7项涉及826名患者的研究.
在DLBCL患者中,升高的sPD-L1显著与糟糕的生存状况 (HR = 2.81) 和劣质的PFS (HR = 3.16) 相关.
较高的sPD-L1与较差的ECOGPS,晚期临床阶段 (III-IV),升高的LDH和高的IPI得分 (3-5) 相关联.

结论:

较高的sPD-L1水平是DLBCL中糟糕的OS和PFS的重要预测因素.
升高的sPD-L1与DLBCL中的侵袭性疾病因素密切相关,突出了其作为预后生物标志物的潜力.

关键词:

在PD-L1中.生物标志物生物标志物循环的循环循环的循环进行元分析分析.幸存率幸存率生存率

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