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与COVID-19病毒载体疫苗相关的安全性和不良影响:系统性审查
SeyedAhmad SeyedAlinaghi1, Ava Pashaei2, Marcarious M Tantuoyir3,4
1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Tanaffos
|February 17, 2025
概括
这次对病毒载体COVID-19疫苗的审查发现,严重的不良事件很少发生. 接种疫苗在预防严重的COVID-19中所带来的好处超过了副作用的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 有关COVID-19疫苗的快速开发存在担忧.
- 系统性审查对于解决安全问题和疫苗犹至关重要.
- 这项研究重点关注与病毒载体COVID-19疫苗相关的不良事件.
研究的目的:
- 系统地审查病毒载体COVID-19疫苗报告的不良事件.
- 提供基于证据的关于腺病毒载体疫苗安全性概况的信息.
- 为公共卫生策略提供信息,并解决疫苗犹.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane数据库中进行系统的文献搜索.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 两步选过程 (标题/摘要和全文) 和使用纽卡斯尔-太华尺度 (NOS) 的偏见评估.
主要成果:
- 审查的腺病毒载体疫苗包括詹森,阿斯特拉泽内卡和斯普特尼克V.
- 阿斯特拉泽内卡疫苗显示显著的系统性副作用 (发烧,疲劳,不适) 和罕见的危及生命的事件 (血栓塞,毛细血管泄漏综合征,死亡).
- 常见的局部反应包括注射部位红血,胀和疼痛. 常见的全身反应包括发烧,疲劳和肌痛.
结论:
- 病毒载体COVID-19疫苗的严重不良事件的发生频率是可以忽略不计的.
- 在预防严重的COVID-19和死亡率方面,接种疫苗的好处明显超过了对一般人口的不良事件风险.
- 证据支持COVID-19大流行背景下病毒载体疫苗的安全性和有效性.
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